note: [link]: hyperlink to the article on journal website
[pmc]: hyperlink to the article on Pubmed Central
[pmc]: hyperlink to the article on Pubmed Central
43. Hao J, Zhao W, Oh JM, Shen K, “A pillar-free diffusion device for studying chemotaxis on supported lipid bilayers”, Micromachines, 2021, 12(10):1254, doi: 10.3390/mi12101254 [link]
42. Begum HM, Mariano C, Zhou H, Shen K, “E-Cadherin Regulates Mitochondrial Membrane Potential in Cancer Cells”, Cancers, 2021; 13(20):5054, doi: 10.3390/cancers13205054 [link]
41. Ando Y, Oh JM, Zhao W, Tran M, Shen K, “Engineering a Vascularized Hypoxic Tumor Model for Therapeutic Assessment”, Cells, 2021; 10(9):2201, doi: 10.3390/cells10092201 [link]
40. Hao J, Zhou H, Nemes K, Yen D, Zhao W, Bramlett C, Wang B, Lu R, Shen K, "Membrane-bound SCF and VCAM-1 synergistically regulate the morphology of hematopoietic stem cells", Journal of Cell Biology, 2021 Oct 4; 220(10):e202010118, doi: 10.1083/jcb.202010118 [link]
* “Spotlight” commentary by Lee and Ding, Journal of Cell Biology (2021) 220 (10): e202108031 [link]
39. Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J, "Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination", Cell Reports, 2021 Jun 29;35(13):109302. doi: 10.1016/j.celrep.2021.109302 [link]
38. Ando Y, Mariano C, Shen K, "Engineered In Vitro Tumor Models for Cell-Based Immunotherapy", Acta Biomaterialia, 2021 Sept 15; 132:345-359, doi: 10.1016/j.actbio.2021.03.076 [link]
37. Trac N, Chen L-Y, Zhang A, Liao C-P, Poon C, Wang J, Ando Y, Joo J, Garri C, Shen K, Kani K, Gross ME, Chung E, “CCR2-targeted micelles for anti-cancer peptide delivery and immune stimulation”, Journal of Controlled Release, 2021 Jan 10;329:614-623. doi: 10.1016/j.jconrel.2020.09.054 [link]
36. Zhang X, Mariano C, Ando Y, Shen K, "Bioengineering Tools for Probing Intracellular Events in T Lymphocytes", WIREs Mechanisms of Disease (formerly known as WIREs Systems Biology and Medicine), 2020, Oct 19;e1510. doi: 10.1002/wsbm.1510 [link]
35. Zhou H, Nguyen L, Arnesano C, Ando Y, Raval M, Rodgers JT, Fraser SE, Lu R, Shen K, "Non-invasive optical biomarkers distinguish and track the metabolic status of single hematopoietic stem cells", iScience, 2020, 23(2) [link]
34. Begum HM, Ta HP, Zhou H, Ando Y, Kang D, Nemes K, Mariano C, Hao J, Yu M, Shen K, “Spatial Regulation of Mitochondrial Heterogeneity by Stromal Confinement in Micropatterned Tumor Models”, Scientific Reports, 2019, Aug 1; 9(1):11187 [link][pmc] (Featured “Top 100 in cell and molecular biology papers in 2019”, out of 2,092 papers)
33. Ando Y, Siegler E, Ta HP, Cinay GE, Zhou H, Gorrel KA, Au H, Jarvis BM, Wang P, Shen K, “Evaluating CAR-T Cell Therapy in a Hypoxic 3-D Tumor Model”, Advanced Healthcare Materials, 2019, Mar 8(5):e1900001 [link][pmc] (Featured as the Front Cover Article [link])
32. Shen K, “Transforming Lung to Treat Type 1 Diabetes”, Science Translational Medicine, 2019, 11(478), doi: 10.1126/scitranslmed.aaw5324 [link]
31. Shen K, “The Virtue of Tolerance”, Science Translational Medicine, 2018, 10(470), doi: 10.1126/scitranslmed.aaw0521 [link]
30. Shen K, “A Nano Stress Reliever for Sepsis”, Science Translational Medicine, 2018, 10(462), doi: 10.1126/scitranslmed.eaav3887 [link]
29. Shen K, “Designer Platelets Pump Up PD-1 Blockade”, Science Translational Medicine, 2018, 10(454), doi: 10.1126/scitranslmed.eaau7389 [link]
28. Shen K, “Improving “Gut Feelings” for Poorly Water-Soluble Drugs”, Science Translational Medicine, 2018, 10(446), doi: 10.1126/scitranslmed.eaau0472 [link]
27. Shen K, “Needles No More”, Science Translational Medicine, 2018, 10(438), doi: 10.1126/scitranslmed.eaat4481 [link]
26. Shen K, “Tumor-Hunting Nanorobots”, Science Translational Medicine, 2018, 10(430), doi: 10.1126/scitranslmed.eaas8968 [link]
25. Ando Y, Ta H, Yen D, Lee S, Raola S, Shen K, “A Microdevice Platform Recapitulating Hypoxic Tumor Microenvironments”, Scientific Reports, 2017, Nov;7(1):15233 [link][pmc] (Featured “Top 100 Scientific Reports Oncology Papers in 2017”)
24. Yen D, Ando Y, Shen K, “A Cost-Effective Micromilling Platform for Rapid Prototyping of Microdevices”, Technology, 2016, Dec;4(4):234-239 [pmc]
23. Shen K*, Luk S, Elman JS, Murray R, Mukundan S, Parekkadan B, “Suicide Gene-Engineered Stromal Cells Reveal a Dynamic Regulation of Cancer Metastasis”, Scientific Reports, 2016, 6:21239 (*: co-corresponding author) [link]
22. Bohr S, Patel SJ, Vasko R, Shen K, Golberg A, Berthiaume F, Yarmush ML, “The Role of CHI3L1 (Chitinase-3-Like-1) in the Pathogenesis of Infections in Burns in a Mouse Model”, PLoS ONE. 2015, 10(11):e0140440 [link]
21. Bohr S, Patel SJ, Vasko R, Shen K, Iracheta-Vellve A, Lee J, Bale SS, Chakraborty N, Brines M, Cerami A, Berthiaume F, Yarmush ML, “Modulation of Cellular Stress Response via the Erythropoietin/CD131 Heteroreceptor Complex in Mouse Mesenchymal-derived Cells”, Journal of Molecular Medicine (Berlin), 2015, Feb;93(2):199-210 [link] [pmc]
20. Shen K*, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan B, “Revealing Cancer-Stroma Interfacial Signaling and Interventions with Micropatterned Tumor-Stromal Assays”, Nature Communications, 2014, 5, doi:10.1038/ncomms6662 (*: co-corresponding author) [link] [pmc]
19. Shen K, Lee J, Yarmush ML, Parekkadan B, “Microcavity Substrates Casted from Self-Assembled Microsphere Monolayers for Spheroid Cell Culture”, Biomedical Microdevices, 2014, 16(4):609-15 [link] [pmc]
18. Elman J, Murray R, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R, Parekkadan B, “Pharmacokinetics of Natural and Engineered Secreted Factors Delivered by Mesenchymal Stromal Cells”, PLoS ONE, 2014, 9(2):e89882 [link]
17. Milwid JM, Elman JS, Li M, Shen K, Manrai A, Gabow A, Jiao Y, Fletcher A, Lee, J, Cima MJ, Yarmush ML, Parekkadan B, “Profiling of Bone Marrow Stromal Cell Secretions Reveals Human MFAP5 and PENK as Potent Stimulators of Endogenous Interleukin-10 Secretion”, Molecular Therapy, 2014, 22(5):999-1007 [link] [pmc]
16. Bashour K, Gondarenko A, Chen H, Shen K, Liu X, Huse M, Hone JC, Kam LC, “CD28 and CD3 Have Complementary Roles in T Cell Traction Forces”, Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(6):2241-6 [link] [pmc]
15. Bashour K, Tsai J, Shen K, Lee JH, Sun E, Milone MC, Dustin ML, Kam LC, "Crosstalk between CD3 and CD28 is Spatially Modulated by Protein Lateral Mobility”, Molecular and Cellular Biology, 2013, 34(6):955-64 [link]
14. Kam L, Shen K, Dustin ML, “Micro- and Nanoscale Engineering of Cell Signaling”, Annual Reviews of Biomedical Engineering, 2013, 2013,15:305-26 [link] [pmc]
13. Bohr S, Patel SJ, Vasko, R, Shen K, Huang G, Yarmush ML, Berthiaume F, “Constitutively Expressed Lhx2 Reflects a Dysregulated, Expanded Epidermal Stem Cell Niche in the Foxn1-/- Nude Mouse Phenotype”, PLoS ONE, 2013, 8(5):e64223 [link]
12. Bohr S, Patel SJ, Shen K, Vitalo AG, Brines M, Cerami A, Berthiaume F, Yarmush ML, “Alternative Erythropoietin-mediated Signaling Prevents Secondary Microvascular Thrombosis and Inflammation within Cutaneous Burns”, Proceedings of the National Academy of Sciences of the United States of America, 2013, 110(9):3413-8 [link] [pmc]
11. Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B, “Implantable Microenvironments to Attract Hematopoietic Stem/Cancer Cells”, Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(48):19638-43 [link] [pmc]
10. O’Connor R, Hao X, Shen K, Bashour K, Kam L, Milone MC, “Substrate Rigidity Regulates ex vivo T Cell Activation and Proliferation”, Journal of Immunology, 2012, 189(3):1330-9 [link]
9. Konry T, Bhushan A, Bale SS, Shen K, Polyak B, Seker E, “Microparticles and Microfluidics Merged: Perspectives of Highly Sensitive Diagnostic Detection”, Microchimica Acta, 2012, 176:251 [pmc]
8. Shen K, Milone MC, Dustin ML, Kam LC, “Nanoengineering of Immune Cell Function”, Materials Research Society Symposium Proceedings, 2009, 1209. [pmc]
7. Shi P, Shen K, Ghassemi S, Hone J, Kam LC, “Dynamic Force Generation by Neural Stem Cells on Elastomer Pillar Arrays”, Cellular and Molecular Bioengineering., 2009, 2(4):464-74 [pmc]
6. Shen K, Tsai J, Shi P, Kam LC, “Self-aligned Supported Lipid Bilayers for Patterning Cell-substrate Interface”, Journal of American Chemical Society, 2009, 131(37):13204-5 [link] [pmc]
5. Shen K, Thomas VK, Dustin ML, Kam LC, “Micropatterning of Costimulatory Ligands Enhances CD4+ T Cell Function”, Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(22):7791-6 [link] [pmc] (Featured “From the Cover”)
4. Shen K, Qi J, Kam LC, “Microcontact Printing of Proteins for Cell Biology”, Journal of Visual Experiments, 2008, (22). pii: 1065. doi: 10.3791/1065 [link] [pmc]
3. Shi P, Shen K, Kam LC, “Local Presentation of L1 and N-cadherin in Multicomponent, Microscale Patterns Differentially Direct Neuron Function in vitro”, Developmental Neurobiology, 2007, 67(13):1765-76 [link]
2. Shen K, Chen X, Guo M, Cheng J, “A Micro Chip-based PCR Device using Flexible Printed Circuit Technology”, Sensors and Actuators B: Chemical, 2005, 105(2):251-8 [link]
1. Chen X, Shen K, Liu P, Guo M, Cheng J, Zhou Y, “Silica-based Solid Phase Extraction of DNA on a Microchip”, Tsinghua Science and Technology, 2004, 4(9):379-83
42. Begum HM, Mariano C, Zhou H, Shen K, “E-Cadherin Regulates Mitochondrial Membrane Potential in Cancer Cells”, Cancers, 2021; 13(20):5054, doi: 10.3390/cancers13205054 [link]
41. Ando Y, Oh JM, Zhao W, Tran M, Shen K, “Engineering a Vascularized Hypoxic Tumor Model for Therapeutic Assessment”, Cells, 2021; 10(9):2201, doi: 10.3390/cells10092201 [link]
40. Hao J, Zhou H, Nemes K, Yen D, Zhao W, Bramlett C, Wang B, Lu R, Shen K, "Membrane-bound SCF and VCAM-1 synergistically regulate the morphology of hematopoietic stem cells", Journal of Cell Biology, 2021 Oct 4; 220(10):e202010118, doi: 10.1083/jcb.202010118 [link]
* “Spotlight” commentary by Lee and Ding, Journal of Cell Biology (2021) 220 (10): e202108031 [link]
39. Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J, "Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination", Cell Reports, 2021 Jun 29;35(13):109302. doi: 10.1016/j.celrep.2021.109302 [link]
38. Ando Y, Mariano C, Shen K, "Engineered In Vitro Tumor Models for Cell-Based Immunotherapy", Acta Biomaterialia, 2021 Sept 15; 132:345-359, doi: 10.1016/j.actbio.2021.03.076 [link]
37. Trac N, Chen L-Y, Zhang A, Liao C-P, Poon C, Wang J, Ando Y, Joo J, Garri C, Shen K, Kani K, Gross ME, Chung E, “CCR2-targeted micelles for anti-cancer peptide delivery and immune stimulation”, Journal of Controlled Release, 2021 Jan 10;329:614-623. doi: 10.1016/j.jconrel.2020.09.054 [link]
36. Zhang X, Mariano C, Ando Y, Shen K, "Bioengineering Tools for Probing Intracellular Events in T Lymphocytes", WIREs Mechanisms of Disease (formerly known as WIREs Systems Biology and Medicine), 2020, Oct 19;e1510. doi: 10.1002/wsbm.1510 [link]
35. Zhou H, Nguyen L, Arnesano C, Ando Y, Raval M, Rodgers JT, Fraser SE, Lu R, Shen K, "Non-invasive optical biomarkers distinguish and track the metabolic status of single hematopoietic stem cells", iScience, 2020, 23(2) [link]
34. Begum HM, Ta HP, Zhou H, Ando Y, Kang D, Nemes K, Mariano C, Hao J, Yu M, Shen K, “Spatial Regulation of Mitochondrial Heterogeneity by Stromal Confinement in Micropatterned Tumor Models”, Scientific Reports, 2019, Aug 1; 9(1):11187 [link][pmc] (Featured “Top 100 in cell and molecular biology papers in 2019”, out of 2,092 papers)
33. Ando Y, Siegler E, Ta HP, Cinay GE, Zhou H, Gorrel KA, Au H, Jarvis BM, Wang P, Shen K, “Evaluating CAR-T Cell Therapy in a Hypoxic 3-D Tumor Model”, Advanced Healthcare Materials, 2019, Mar 8(5):e1900001 [link][pmc] (Featured as the Front Cover Article [link])
32. Shen K, “Transforming Lung to Treat Type 1 Diabetes”, Science Translational Medicine, 2019, 11(478), doi: 10.1126/scitranslmed.aaw5324 [link]
31. Shen K, “The Virtue of Tolerance”, Science Translational Medicine, 2018, 10(470), doi: 10.1126/scitranslmed.aaw0521 [link]
30. Shen K, “A Nano Stress Reliever for Sepsis”, Science Translational Medicine, 2018, 10(462), doi: 10.1126/scitranslmed.eaav3887 [link]
29. Shen K, “Designer Platelets Pump Up PD-1 Blockade”, Science Translational Medicine, 2018, 10(454), doi: 10.1126/scitranslmed.eaau7389 [link]
28. Shen K, “Improving “Gut Feelings” for Poorly Water-Soluble Drugs”, Science Translational Medicine, 2018, 10(446), doi: 10.1126/scitranslmed.eaau0472 [link]
27. Shen K, “Needles No More”, Science Translational Medicine, 2018, 10(438), doi: 10.1126/scitranslmed.eaat4481 [link]
26. Shen K, “Tumor-Hunting Nanorobots”, Science Translational Medicine, 2018, 10(430), doi: 10.1126/scitranslmed.eaas8968 [link]
25. Ando Y, Ta H, Yen D, Lee S, Raola S, Shen K, “A Microdevice Platform Recapitulating Hypoxic Tumor Microenvironments”, Scientific Reports, 2017, Nov;7(1):15233 [link][pmc] (Featured “Top 100 Scientific Reports Oncology Papers in 2017”)
24. Yen D, Ando Y, Shen K, “A Cost-Effective Micromilling Platform for Rapid Prototyping of Microdevices”, Technology, 2016, Dec;4(4):234-239 [pmc]
23. Shen K*, Luk S, Elman JS, Murray R, Mukundan S, Parekkadan B, “Suicide Gene-Engineered Stromal Cells Reveal a Dynamic Regulation of Cancer Metastasis”, Scientific Reports, 2016, 6:21239 (*: co-corresponding author) [link]
22. Bohr S, Patel SJ, Vasko R, Shen K, Golberg A, Berthiaume F, Yarmush ML, “The Role of CHI3L1 (Chitinase-3-Like-1) in the Pathogenesis of Infections in Burns in a Mouse Model”, PLoS ONE. 2015, 10(11):e0140440 [link]
21. Bohr S, Patel SJ, Vasko R, Shen K, Iracheta-Vellve A, Lee J, Bale SS, Chakraborty N, Brines M, Cerami A, Berthiaume F, Yarmush ML, “Modulation of Cellular Stress Response via the Erythropoietin/CD131 Heteroreceptor Complex in Mouse Mesenchymal-derived Cells”, Journal of Molecular Medicine (Berlin), 2015, Feb;93(2):199-210 [link] [pmc]
20. Shen K*, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan B, “Revealing Cancer-Stroma Interfacial Signaling and Interventions with Micropatterned Tumor-Stromal Assays”, Nature Communications, 2014, 5, doi:10.1038/ncomms6662 (*: co-corresponding author) [link] [pmc]
19. Shen K, Lee J, Yarmush ML, Parekkadan B, “Microcavity Substrates Casted from Self-Assembled Microsphere Monolayers for Spheroid Cell Culture”, Biomedical Microdevices, 2014, 16(4):609-15 [link] [pmc]
18. Elman J, Murray R, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R, Parekkadan B, “Pharmacokinetics of Natural and Engineered Secreted Factors Delivered by Mesenchymal Stromal Cells”, PLoS ONE, 2014, 9(2):e89882 [link]
17. Milwid JM, Elman JS, Li M, Shen K, Manrai A, Gabow A, Jiao Y, Fletcher A, Lee, J, Cima MJ, Yarmush ML, Parekkadan B, “Profiling of Bone Marrow Stromal Cell Secretions Reveals Human MFAP5 and PENK as Potent Stimulators of Endogenous Interleukin-10 Secretion”, Molecular Therapy, 2014, 22(5):999-1007 [link] [pmc]
16. Bashour K, Gondarenko A, Chen H, Shen K, Liu X, Huse M, Hone JC, Kam LC, “CD28 and CD3 Have Complementary Roles in T Cell Traction Forces”, Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(6):2241-6 [link] [pmc]
15. Bashour K, Tsai J, Shen K, Lee JH, Sun E, Milone MC, Dustin ML, Kam LC, "Crosstalk between CD3 and CD28 is Spatially Modulated by Protein Lateral Mobility”, Molecular and Cellular Biology, 2013, 34(6):955-64 [link]
14. Kam L, Shen K, Dustin ML, “Micro- and Nanoscale Engineering of Cell Signaling”, Annual Reviews of Biomedical Engineering, 2013, 2013,15:305-26 [link] [pmc]
13. Bohr S, Patel SJ, Vasko, R, Shen K, Huang G, Yarmush ML, Berthiaume F, “Constitutively Expressed Lhx2 Reflects a Dysregulated, Expanded Epidermal Stem Cell Niche in the Foxn1-/- Nude Mouse Phenotype”, PLoS ONE, 2013, 8(5):e64223 [link]
12. Bohr S, Patel SJ, Shen K, Vitalo AG, Brines M, Cerami A, Berthiaume F, Yarmush ML, “Alternative Erythropoietin-mediated Signaling Prevents Secondary Microvascular Thrombosis and Inflammation within Cutaneous Burns”, Proceedings of the National Academy of Sciences of the United States of America, 2013, 110(9):3413-8 [link] [pmc]
11. Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B, “Implantable Microenvironments to Attract Hematopoietic Stem/Cancer Cells”, Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(48):19638-43 [link] [pmc]
10. O’Connor R, Hao X, Shen K, Bashour K, Kam L, Milone MC, “Substrate Rigidity Regulates ex vivo T Cell Activation and Proliferation”, Journal of Immunology, 2012, 189(3):1330-9 [link]
9. Konry T, Bhushan A, Bale SS, Shen K, Polyak B, Seker E, “Microparticles and Microfluidics Merged: Perspectives of Highly Sensitive Diagnostic Detection”, Microchimica Acta, 2012, 176:251 [pmc]
8. Shen K, Milone MC, Dustin ML, Kam LC, “Nanoengineering of Immune Cell Function”, Materials Research Society Symposium Proceedings, 2009, 1209. [pmc]
7. Shi P, Shen K, Ghassemi S, Hone J, Kam LC, “Dynamic Force Generation by Neural Stem Cells on Elastomer Pillar Arrays”, Cellular and Molecular Bioengineering., 2009, 2(4):464-74 [pmc]
6. Shen K, Tsai J, Shi P, Kam LC, “Self-aligned Supported Lipid Bilayers for Patterning Cell-substrate Interface”, Journal of American Chemical Society, 2009, 131(37):13204-5 [link] [pmc]
5. Shen K, Thomas VK, Dustin ML, Kam LC, “Micropatterning of Costimulatory Ligands Enhances CD4+ T Cell Function”, Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(22):7791-6 [link] [pmc] (Featured “From the Cover”)
4. Shen K, Qi J, Kam LC, “Microcontact Printing of Proteins for Cell Biology”, Journal of Visual Experiments, 2008, (22). pii: 1065. doi: 10.3791/1065 [link] [pmc]
3. Shi P, Shen K, Kam LC, “Local Presentation of L1 and N-cadherin in Multicomponent, Microscale Patterns Differentially Direct Neuron Function in vitro”, Developmental Neurobiology, 2007, 67(13):1765-76 [link]
2. Shen K, Chen X, Guo M, Cheng J, “A Micro Chip-based PCR Device using Flexible Printed Circuit Technology”, Sensors and Actuators B: Chemical, 2005, 105(2):251-8 [link]
1. Chen X, Shen K, Liu P, Guo M, Cheng J, Zhou Y, “Silica-based Solid Phase Extraction of DNA on a Microchip”, Tsinghua Science and Technology, 2004, 4(9):379-83
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