note: [link]: hyperlink to the article on journal website
[pmc]: hyperlink to the article on Pubmed Central
[pmc]: hyperlink to the article on Pubmed Central
25. Ando Y, Ta H, Yen D, Lee S, Raola S, Shen K, “A Microdevice Platform Recapitulating Hypoxic Tumor Microenvironments”, Sci Rep, Accepted
24. Yen D, Ando Y, Shen K, “A Cost-Effective Micromilling Platform for Rapid Prototyping of Microdevices”, Technology, 2016, Dec;4(4):234-239 [pmc]
23. Shen K*, Luk S, Elman JS, Murray R, Mukundan S, Parekkadan B, “Suicide Gene-Engineered Stromal Cells Reveal a Dynamic Regulation of Cancer Metastasis”, Sci Rep, 2016, 6:21239 (*: co-corresponding author) [link]
22. Bohr S, Patel SJ, Vasko R, Shen K, Golberg A, Berthiaume F, Yarmush ML, “The Role of CHI3L1 (Chitinase-3-Like-1) in the Pathogenesis of Infections in Burns in a Mouse Model”, PLoS ONE. 2015, 10(11):e0140440 [link]
21. Bohr S, Patel SJ, Vasko R, Shen K, Iracheta-Vellve A, Lee J, Bale SS, Chakraborty N, Brines M, Cerami A, Berthiaume F, Yarmush ML, “Modulation of Cellular Stress Response via the Erythropoietin/CD131 Heteroreceptor Complex in Mouse Mesenchymal-derived Cells”, J Mol Med (Berl), 2015, Feb;93(2):199-210 [link] [pmc]
20. Shen K*, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan B, “Revealing Cancer-Stroma Interfacial Signaling and Interventions with Micropatterned Tumor-Stromal Assays”, Nat. Commun., 2014, 5, doi:10.1038/ncomms6662 (*: co-corresponding author) [link] [pmc]
19. Shen K, Lee J, Yarmush ML, Parekkadan B, “Microcavity Substrates Casted from Self-Assembled Microsphere Monolayers for Spheroid Cell Culture”, Biomed. Microdevices, 2014, 16(4):609-15 [link] [pmc]
18. Elman J, Murray R, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R, Parekkadan B, “Pharmacokinetics of Natural and Engineered Secreted Factors Delivered by Mesenchymal Stromal Cells”, PLoS ONE, 2014, 9(2):e89882 [link]
17. Milwid JM, Elman JS, Li M, Shen K, Manrai A, Gabow A, Jiao Y, Fletcher A, Lee, J, Cima MJ, Yarmush ML, Parekkadan B, “Profiling of Bone Marrow Stromal Cell Secretions Reveals Human MFAP5 and PENK as Potent Stimulators of Endogenous Interleukin-10 Secretion”, Mol. Ther., 2014, 22(5):999-1007 [link] [pmc]
16. Bashour K, Gondarenko A, Chen H, Shen K, Liu X, Huse M, Hone JC, Kam LC, “CD28 and CD3 Have Complementary Roles in T Cell Traction Forces”, Proc. Natl. Acad. Sci. U S A, 2014, 111(6):2241-6 [link] [pmc]
15. Bashour K, Tsai J, Shen K, Lee JH, Sun E, Milone MC, Dustin ML, Kam LC, "Crosstalk between CD3 and CD28 is Spatially Modulated by Protein Lateral Mobility”, Mol. Cell. Biol., 2013, 34(6):955-64 [link]
14. Kam L, Shen K, Dustin ML, “Micro- and Nanoscale Engineering of Cell Signaling”, Annu. Rev. Biomed. Eng., 2013, 2013,15:305-26 [link] [pmc]
13. Bohr S, Patel SJ, Vasko, R, Shen K, Huang G, Yarmush ML, Berthiaume F, “Constitutively Expressed Lhx2 Reflects a Dysregulated, Expanded Epidermal Stem Cell Niche in the Foxn1-/- Nude Mouse Phenotype”, PLoS ONE, 2013, 8(5):e64223 [link]
12. Bohr S, Patel SJ, Shen K, Vitalo AG, Brines M, Cerami A, Berthiaume F, Yarmush ML, “Alternative Erythropoietin-mediated Signaling Prevents Secondary Microvascular Thrombosis and Inflammation within Cutaneous Burns”, Proc. Natl. Acad. Sci. U S A, 2013, 110(9):3413-8 [link] [pmc]
11. Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B, “Implantable Microenvironments to Attract Hematopoietic Stem/Cancer Cells”, Proc. Natl. Acad. Sci. U S A, 2012, 109(48):19638-43 [link] [pmc]
10. O’Connor R, Hao X, Shen K, Bashour K, Kam L, Milone MC, “Substrate Rigidity Regulates ex vivo T Cell Activation and Proliferation”, J. Immunol., 2012, 189(3):1330-9 [link]
9. Konry T, Bhushan A, Bale SS, Shen K, Polyak B, Seker E, “Microparticles and Microfluidics Merged: Perspectives of Highly Sensitive Diagnostic Detection”, Microchim. Acta, 2012, 176:251 [pmc]
8. Shen K, Milone MC, Dustin ML, Kam LC, “Nanoengineering of Immune Cell Function”, Mater. Res. Soc. Symp. Proc., 2009, 1209. [pmc]
7. Shi P, Shen K, Ghassemi S, Hone J, Kam LC, “Dynamic Force Generation by Neural Stem Cells on Elastomer Pillar Arrays”, Cell. Mol. Bioeng., 2009, 2(4):464-74 [pmc]
6. Shen K, Tsai J, Shi P, Kam LC, “Self-aligned Supported Lipid Bilayers for Patterning Cell-substrate Interface”, J. Am. Chem. Soc., 2009, 131(37):13204-5 [link] [pmc]
5. Shen K, Thomas VK, Dustin ML, Kam LC, “Micropatterning of Costimulatory Ligands Enhances CD4+ T Cell Function”, Proc. Natl. Acad. Sci. U S A, 2008, 105(22):7791-6 (Featured “From the Cover”) [link] [pmc]
4. Shen K, Qi J, Kam LC, “Microcontact Printing of Proteins for Cell Biology”, J. Vis. Exp., 2008, (22). pii: 1065. doi: 10.3791/1065 [link] [pmc]
3. Shi P, Shen K, Kam LC, “Local Presentation of L1 and N-cadherin in Multicomponent, Microscale Patterns Differentially Direct Neuron Function in vitro”, Dev. Neurobiol., 2007, 67(13):1765-76 [link]
2. Shen K, Chen X, Guo M, Cheng J, “A Micro Chip-based PCR Device using Flexible Printed Circuit Technology”, Sensor. Actuat. B-Chem., 2005, 105(2):251-8 [link]
1. Chen X, Shen K, Liu P, Guo M, Cheng J, Zhou Y, “Silica-based Solid Phase Extraction of DNA on a Microchip”, Tsinghua Sci. Technol., 2004, 4(9):379-83
24. Yen D, Ando Y, Shen K, “A Cost-Effective Micromilling Platform for Rapid Prototyping of Microdevices”, Technology, 2016, Dec;4(4):234-239 [pmc]
23. Shen K*, Luk S, Elman JS, Murray R, Mukundan S, Parekkadan B, “Suicide Gene-Engineered Stromal Cells Reveal a Dynamic Regulation of Cancer Metastasis”, Sci Rep, 2016, 6:21239 (*: co-corresponding author) [link]
22. Bohr S, Patel SJ, Vasko R, Shen K, Golberg A, Berthiaume F, Yarmush ML, “The Role of CHI3L1 (Chitinase-3-Like-1) in the Pathogenesis of Infections in Burns in a Mouse Model”, PLoS ONE. 2015, 10(11):e0140440 [link]
21. Bohr S, Patel SJ, Vasko R, Shen K, Iracheta-Vellve A, Lee J, Bale SS, Chakraborty N, Brines M, Cerami A, Berthiaume F, Yarmush ML, “Modulation of Cellular Stress Response via the Erythropoietin/CD131 Heteroreceptor Complex in Mouse Mesenchymal-derived Cells”, J Mol Med (Berl), 2015, Feb;93(2):199-210 [link] [pmc]
20. Shen K*, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan B, “Revealing Cancer-Stroma Interfacial Signaling and Interventions with Micropatterned Tumor-Stromal Assays”, Nat. Commun., 2014, 5, doi:10.1038/ncomms6662 (*: co-corresponding author) [link] [pmc]
19. Shen K, Lee J, Yarmush ML, Parekkadan B, “Microcavity Substrates Casted from Self-Assembled Microsphere Monolayers for Spheroid Cell Culture”, Biomed. Microdevices, 2014, 16(4):609-15 [link] [pmc]
18. Elman J, Murray R, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R, Parekkadan B, “Pharmacokinetics of Natural and Engineered Secreted Factors Delivered by Mesenchymal Stromal Cells”, PLoS ONE, 2014, 9(2):e89882 [link]
17. Milwid JM, Elman JS, Li M, Shen K, Manrai A, Gabow A, Jiao Y, Fletcher A, Lee, J, Cima MJ, Yarmush ML, Parekkadan B, “Profiling of Bone Marrow Stromal Cell Secretions Reveals Human MFAP5 and PENK as Potent Stimulators of Endogenous Interleukin-10 Secretion”, Mol. Ther., 2014, 22(5):999-1007 [link] [pmc]
16. Bashour K, Gondarenko A, Chen H, Shen K, Liu X, Huse M, Hone JC, Kam LC, “CD28 and CD3 Have Complementary Roles in T Cell Traction Forces”, Proc. Natl. Acad. Sci. U S A, 2014, 111(6):2241-6 [link] [pmc]
15. Bashour K, Tsai J, Shen K, Lee JH, Sun E, Milone MC, Dustin ML, Kam LC, "Crosstalk between CD3 and CD28 is Spatially Modulated by Protein Lateral Mobility”, Mol. Cell. Biol., 2013, 34(6):955-64 [link]
14. Kam L, Shen K, Dustin ML, “Micro- and Nanoscale Engineering of Cell Signaling”, Annu. Rev. Biomed. Eng., 2013, 2013,15:305-26 [link] [pmc]
13. Bohr S, Patel SJ, Vasko, R, Shen K, Huang G, Yarmush ML, Berthiaume F, “Constitutively Expressed Lhx2 Reflects a Dysregulated, Expanded Epidermal Stem Cell Niche in the Foxn1-/- Nude Mouse Phenotype”, PLoS ONE, 2013, 8(5):e64223 [link]
12. Bohr S, Patel SJ, Shen K, Vitalo AG, Brines M, Cerami A, Berthiaume F, Yarmush ML, “Alternative Erythropoietin-mediated Signaling Prevents Secondary Microvascular Thrombosis and Inflammation within Cutaneous Burns”, Proc. Natl. Acad. Sci. U S A, 2013, 110(9):3413-8 [link] [pmc]
11. Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B, “Implantable Microenvironments to Attract Hematopoietic Stem/Cancer Cells”, Proc. Natl. Acad. Sci. U S A, 2012, 109(48):19638-43 [link] [pmc]
10. O’Connor R, Hao X, Shen K, Bashour K, Kam L, Milone MC, “Substrate Rigidity Regulates ex vivo T Cell Activation and Proliferation”, J. Immunol., 2012, 189(3):1330-9 [link]
9. Konry T, Bhushan A, Bale SS, Shen K, Polyak B, Seker E, “Microparticles and Microfluidics Merged: Perspectives of Highly Sensitive Diagnostic Detection”, Microchim. Acta, 2012, 176:251 [pmc]
8. Shen K, Milone MC, Dustin ML, Kam LC, “Nanoengineering of Immune Cell Function”, Mater. Res. Soc. Symp. Proc., 2009, 1209. [pmc]
7. Shi P, Shen K, Ghassemi S, Hone J, Kam LC, “Dynamic Force Generation by Neural Stem Cells on Elastomer Pillar Arrays”, Cell. Mol. Bioeng., 2009, 2(4):464-74 [pmc]
6. Shen K, Tsai J, Shi P, Kam LC, “Self-aligned Supported Lipid Bilayers for Patterning Cell-substrate Interface”, J. Am. Chem. Soc., 2009, 131(37):13204-5 [link] [pmc]
5. Shen K, Thomas VK, Dustin ML, Kam LC, “Micropatterning of Costimulatory Ligands Enhances CD4+ T Cell Function”, Proc. Natl. Acad. Sci. U S A, 2008, 105(22):7791-6 (Featured “From the Cover”) [link] [pmc]
4. Shen K, Qi J, Kam LC, “Microcontact Printing of Proteins for Cell Biology”, J. Vis. Exp., 2008, (22). pii: 1065. doi: 10.3791/1065 [link] [pmc]
3. Shi P, Shen K, Kam LC, “Local Presentation of L1 and N-cadherin in Multicomponent, Microscale Patterns Differentially Direct Neuron Function in vitro”, Dev. Neurobiol., 2007, 67(13):1765-76 [link]
2. Shen K, Chen X, Guo M, Cheng J, “A Micro Chip-based PCR Device using Flexible Printed Circuit Technology”, Sensor. Actuat. B-Chem., 2005, 105(2):251-8 [link]
1. Chen X, Shen K, Liu P, Guo M, Cheng J, Zhou Y, “Silica-based Solid Phase Extraction of DNA on a Microchip”, Tsinghua Sci. Technol., 2004, 4(9):379-83
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